Endocrine Abstracts

Cellular Ca2+ signals have been proposed to activate signal for hormone secretion. In pancreatic β cell which produce insulin, Ca2+ signals have been known contributing insulin secretion. Prior to conduct this study, we confirmed calbindin-D9k (CaBP-9k) which responsible for regulation of the distribution offree calcium in the cytoplasm. Hypoxic condition induces endoplasmic reticulum(ER) stress, increase both insulin signaling and insulin resistance. Byexposing hypoxia, ...

Calcium is important for physiological functioning in many tissues and is essential in mucus secretion and muscle contraction. Intracellular concentrations of calcium are regulated by calcium-related proteins such as TRPV4, TRPV6, CaBP-9k, NCX1, and PMCA1. In this study, the relationship between secretion of pulmonary mucus and calcium regulation was investigated. To confirm the effect of steroid hormones, immature mice were injected with estrogen (E2) or progesterone (P4) and...

Introduction: Calbindin-D9k is a 9 kDa polypeptide expressed in the mammalian intestine, uterus, and pituitary gland. Calbindin-D9k increase Ca2+ absorption by buffering intracellular Ca2+. The intracellular concentration of calcium is regulated by calcium related proteins such as calbindin-D9k, TRPV1 and PMCA1. The regulatory effect of steroid hormones and glucocorticoids on calbindin-D9k, TRPV1 and PMCA1 expre...